Jean-pierre gnimatin
Research Unit of Applied Microbiology and Pharmacology of natural substances
Title: Mathematical modelling of resistance among uropathogenic klebsiella pneumoniae strains to some
Biography
Biography: Jean-pierre gnimatin
Abstract
The issue of bacterial resistance to antibiotics is a major global public health problem, particularly in developing countries such as Benin. The general objective of this study was to contribute to the resolution of antibiotic resistance problem of Klebsiella pneumoniae strains. For this purpose, forty-eight (48) strains of Klebsiella pneumoniae isolated from four (4) laboratories in southern Benin were collected during the period from May 13 to August 02, 2019. Conventional microbiological manipulation techniques were used for identification of strains of Klebsiella pneumoniae. The resistance profile of the strains against antibiotics was determined according to the methodology recommended by the French Society of Microbiology 2019. Mathematical modeling of the resistance of strains was made using deterministic compartmental models. Results for the antibiotic susceptibility test showed high penicillin resistance, moderate resistance to cephalosporins and fluoroquinolones, and low resistance to carbapenems. The mathematical modelling made it possible to project the resistance of Klebsiella pneumoniae strains at the horizon 2024. Thus, a high frequency of resistance was observed to almost all the antibiotics tested. Only Imipenem, which in 2019 showed a resistance rate of 6.19%, will have a moderately low resistance rate (34.80%) in 2024. These results demonstrate an urgent need for surveillance and control of antibiotic resistance in Benin and urge to explore new sources such as medicinal plants.