Drug Discovery Technologies in Antibiotics

Infectious diseases account for nearly one fifth of the worldwide death toll every year. The constant increase of drug‐resistant pathogens is a big challenge for treatment of infectious diseases. In addition, outbreaks of infections and new pathogens are potential threats to public health. Lack of effective treatments for drug‐resistant bacteria and recent outbreaks of Ebola and Zika viral infections have become a global public health concern. The number of newly approved antibiotics has decreased significantly in the last two decades compared with previous decades. In parallel with this, is an increase in the number of drug‐resistant bacteria. For these threats and challenges to be countered, new strategies and technology platforms are critically needed. Drug remodelling has emerged as an approach for rapid identification of effective therapeutics to treat the infectious diseases.

  • Antimicrobial resistance
  • Applications to exploit actinomycetes as a resource for new antibiotics
  • Antimicrobials by immune stimulation
  • Molecular and functional genomic approaches to novel antibacterial target discovery
  • Improved microbial identification

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